Phosphatidylserine 100mg - 100 capsules

Phosphatidylserine (PS) is a phospholipid that forms an integral part of cell membranes in the body. It is especially prevalent in brain cells, playing a critical role in neuronal structure and function. Phosphatidylserine can be synthesized by the body, but it is also obtained through diet and supplements.

Why is it considered a nootropic? Phosphatidylserine is considered a nootropic due to its positive influence on brain function. It is involved in activities that help maintain brain health, improve memory, concentration and learning, and support overall mental health.

Mechanism of action:

• Integration into cell membranes : Once ingested, PS integrates into cell membranes, strengthening their structure and fluidity.
• Facilitation of neurotransmission : By improving membrane fluidity, PS can enhance the release of neurotransmitters and optimize the function of receptors in brain cells.
• Modulation of kinase activity : PS can influence enzymes (kinases) that affect signal transduction in cells, which could have implications for learning and memory.

Benefits :

1. Improvement in Cognitive Function :
   • Memory : Studies have shown that PS supplementation can specifically improve working and short-term memory. This is especially relevant for elderly individuals or those with the beginnings of cognitive decline.
   • Learning : PS has been shown to facilitate the brain's ability to consolidate new information, which is crucial to the learning process.
   • Attention : The ability to maintain attention and focus on specific tasks appears to improve with PS supplementation.
2. Neuronal Protection :
   • Preventing oxidative stress : PS may help protect brain cells from damage caused by free radicals, which in turn may help prevent neurodegenerative diseases.
   • Supporting the integrity of cell membranes : By strengthening the cell membrane, PS can support optimal cell function and its ability to communicate with other cells.
3. Mood Health :
   • Reduction of depressive symptoms : Some research indicates that PS may be beneficial for people with symptoms of depression, especially in elderly people with depression associated with cognitive decline.
   • Stress Management : By reducing cortisol production in response to stress, PS may help maintain a more balanced mood during periods of stress.
4. Benefits for Athletes :
   • Muscle recovery : PS can accelerate post-exercise recovery by reducing muscle damage and decreasing fatigue.
   • Cognitive performance during exercise : In sports that require quick decision making, PS could enhance the ability to think clearly under physically stressful conditions.
5. Aging Support :
   • Preventing Cognitive Decline : Phosphatidylserine may help slow the age-related decline of brain functions, including memory and processing ability.
   • Improved Social Interaction : In the elderly, improved cognitive function can lead to a better quality of life and more social interactions, reducing the risk of isolation.
6. Potential in the Treatment of Autism Spectrum Disorders (ASD) : Some preliminary studies suggest that phosphatidylserine could have a positive impact on certain symptoms of ASD, although more research is required in this area.
7. Sleep : There is evidence to suggest that phosphatidylserine may improve sleep quality, especially in those with insomnia or disturbed sleep patterns.

Absorption : Phosphatidylserine is efficiently absorbed in the small intestine. Its bioavailability can be improved if taken together with fatty foods.

Adverse effects and contraindications :

• Adverse effects : PS is generally safe when taken at recommended doses. However, some users have reported mild side effects, such as insomnia or stomach pain.
• Contraindications : While PS is safe for most people, those taking anticoagulant or antiplatelet medications should consult a healthcare professional before beginning supplementation, as PS could potentiate the effects of these medications.
• Drug Interactions : Caution is advised when combining PS with medications that affect blood clotting, anticholinergic medications, or those that affect serotonin.

It is important to consult a health professional before incorporating phosphatidylserine or any other supplement into your daily routine.

More information about Phosphatidylserine and its dosage: https://nootropicsexpert.com/phosphatidylserine-ps/

References on studies:

[i] De Simone R., Ajmone-Cat MA, Tirassa P., Minghetti L. “Apoptotic PC12 cells exposing phosphatidylserine promote the production of anti-inflammatory and neuroprotective molecules by microglial cells.” Journal of Neuropathology and Experimental Neurology . 2003 Feb;62(2):208-16. ( source )

[ii] Kosicek M., Hecimovic S. “Phospholipids and Alzheimer's Disease: Alterations, Mechanisms and Potential Biomarkers” International Journal of Molecular Science . 2013 Jan; 14(1): 1310–1322. ( source )

[iii] Crook TH, Tinklenberg J., Yesavage J., Petrie W., Nunzi MG, Massari DC “Effects of phosphatidylserine in age-associated memory impairment.” Neurology . 1991 May;41(5):644-9. ( source )

[iv] Cunnane SC, Schneider JA, Tangney C., Tremblay-Mercier J., Fortier M., Bennett DA, Morris MC “Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease.” Journal of Alzheimer's Disease . 2012;29(3):691-7. ( source )

[v] Monteleone P., Beinat L., Tanzillo C., Maj M., Kemali D. “Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans.” Neuroendocrinology . 1990 Sep;52(3):243-8. ( source )

[vi] Benton D., Donohoe RT, Sillance B., Nabb S. “The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor.” Nutritional Neuroscience . 2001;4(3):169-78. ( source )

[vii] Baumeister J., Barthel T., Geiss KR, Weiss M. “Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress.” Nutritional Neuroscience . 2008 Jun;11(3):103-10. ( source )

[viii] Benton D., Donohoe RT, Sillance B., Nabb S. “The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor.” Nutritional Neuroscience . 2001;4(3):169-78. ( source )

[ix] Parker AG, Gordon J., Thornton A., Byars A., Lubker J., Bartlett M., Byrd M., Oliver J., Simbo S., Rasmussen C., Greenwood M., Kreider RB “The effects of IQPLUS Focus on cognitive function, mood and endocrine response before and following acute exercise.” Journal of the International Society of Sports Nutrition . 2011 Oct 21;8:16 ( source )

[x] Hirayama S., Terasawa K., Rabeler R., Hirayama T., Inoue T., Tatsumi Y., Purpura M., Jäger R. “The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder : a randomized, double-blind, placebo-controlled clinical trial.” Journal of Human Nutrition and Dietetics . 2014 Apr;27 Suppl 2:284-91. ( source )

[xi] Manor I., Magen A., Keidar D., Rosen S., Tasker H., Cohen T., Richter Y., Zaaroor-Regev D., Manor Y., Weizman A. “The effect of phosphatidylserine containing “Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: a double-blind placebo-controlled trial, followed by an open-label extension.” European Psychiatry . 2012 Jul;27(5):335-42. ( source )

[xii] Schreiber S., Kampf-Sherf O., Gorfine M., Kelly D., Oppenheim Y., Lerer B. “An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline.” Israeli Journal of Psychiatry and Related Sciences . 2000;37(4):302-7. ( source )

[xiii] Crook T., Petrie W., Wells C., Massari DC “Effects of phosphatidylserine in Alzheimer's disease.” Psychopharmacology Bulletin . 1992;28(1):61-6. ( source )