Tianeptine 25mg - 50 capsules

Tianeptine is an atypical drug used primarily as an antidepressant. Unlike most antidepressants that primarily affect the neurotransmitters serotonin or norepinephrine, tianeptine has a unique mechanism of action that sets it apart. Due to its effects on cognition and mood, it has also gained attention as a possible nootropic.

Why is it considered a nootropic? Although tianeptine is primarily known as an antidepressant, it has properties that improve cognitive function, learning ability, and memory in some people, particularly those with depressive or anxious states. These benefits, along with its ability to improve mood, lead some people to consider it within the realm of nootropics.

Mechanism of action : The exact mechanism of action of tianeptine is complex and not completely defined. Unlike other antidepressants, it does not act primarily by inhibiting serotonin reuptake. It is thought to have a modulatory effect on glutamatergic receptors in the brain, in particular facilitating glutamatergic neurotransmission in the hippocampus and prefrontal cortex. Additionally, it may have neuroprotective and anti-inflammatory properties that contribute to its effects.

Benefits of Tianeptine :

1. Antidepressant : It is effective in treating depressive symptoms, improving mood and reducing anhedonia (inability to feel pleasure).
2. Anxiolytic : May reduce anxiety symptoms in some users without the sedative effects common to many anxiolytics.
3. Cognitive improvement : In individuals with depression or anxiety, tianeptine may improve cognition, memory, and learning ability.
4. Neuroprotective properties : May protect neurons from stress and toxicity, which could be beneficial for long-term brain health.
5. Stress reduction : Tianeptine may reduce the effects of chronic stress on the brain, protecting against stress-related damage and dysfunction.
6. Optimizing cognitive performance : May improve mental clarity, attention, and focus, especially in those with mood disorders.
7. Adaptogenic effects : Helps the body and brain adapt to stress and changing situations.
8. Pain Modulation : Tianeptine has been suggested to have analgesic properties, particularly in neuropathic pain.

Absorption:

1. Solubility : Tianeptine is relatively water soluble. However, its solubility does not significantly affect its oral absorption, which is quite efficient.
2. Oral route : Tianeptine is usually taken orally, either in tablet or capsule form. Its absorption in the gastrointestinal tract is quite rapid, reaching maximum levels in plasma in about an hour after ingestion.
3. With or without food : It can be taken with or without food. Although food may slow the rate of absorption somewhat, it does not affect the total amount of medication that is absorbed.
4. Additional Considerations : Although not directly related to absorption, it is important to mention that tianeptine has abuse and dependence potential. At doses much higher than recommended, there have been reports of abuse of tianeptine, which can lead to withdrawal symptoms when use is stopped.

Tianeptine Adverse Effects: Although it is considered safe and is generally very well tolerated for the vast majority, for some there may be certain side effects and contraindications to consider.

1. Headache: Some users report headaches after tianeptine consumption.
2. Nausea: Like many other medications, it may cause stomach upset or nausea in some individuals.
3. Dry mouth: This is a common side effect of many medications and can occur with tianeptine.
4. Drowsiness or insomnia: Although it may cause drowsiness in some, others report insomnia.
5. Dependence and withdrawal syndrome: Cases of abuse of tianeptine have been reported, leading to dependence and withdrawal symptoms when the medication is discontinued.
6. Gastrointestinal effects: Including diarrhea or constipation.

Contraindications of Tianeptine:

1. Drug interactions: Tianeptine may interact with other medications, particularly with other antidepressants or substances that affect the central nervous system.
2. Pre-existing medical conditions: People with certain medical conditions, particularly those related to the nervous or liver system, should exercise caution and consult a doctor before starting tianeptine.
3. Pregnancy and breast-feeding: While research is limited, it is generally advised not to use tianeptine during pregnancy or breast-feeding unless absolutely necessary and under the guidance of a doctor.
4. Substance Abuse: Given the potential for dependence on tianeptine, those with a history of substance abuse should be particularly cautious.
5. Other antidepressants: Due to possible interactions, tianeptine should generally not be taken with other antidepressants without appropriate medical consultation.

It is important to emphasize that, while tianeptine has a variety of potential benefits, the effects may vary between individuals. It is always essential that users do their own research and, if possible, consult with a health professional before incorporating it into their routine.