Pramiracetam 600mg - 50 Capsules

Pramiracetam is a compound derived from piracetam and belongs to the racetam family. This family is widely known for its ability to improve cognitive functions. Although similar in structure to piracetam, pramiracetam is significantly more potent and has unique characteristics that distinguish it from other racetams.

Why is it considered a nootropic? A nootropic is a substance that enhances cognitive ability without causing toxicity or serious side effects. Pramiracetam fits this definition because of its ability to improve memory, concentration, and other cognitive functions without causing damage to the nervous system or brain chemical balance.

Mechanism of action : Although the exact mechanism of action of pramiracetam is still being investigated, it is believed to act primarily by increasing the release of acetylcholine in the hippocampus, a brain region essential for memory and learning. Acetylcholine is a neurotransmitter crucial for cognitive function. Additionally, pramiracetam can improve the fluidity of neuronal cell membranes, facilitating synaptic transmission and communication between nerve cells.

Pramiracetam Benefits :

1. Memory improvement : It is widely recognized for its ability to enhance short- and long-term memory.
2. Increased concentration : Users report an increased ability to focus on specific tasks and maintain attention for long periods.
3. Enhancement of learning : Facilitates the acquisition and retention of new information, which can be beneficial for students and professionals.
4. Mood improvement : Some users experience an increase in mental clarity and elevated mood, reducing mild symptoms of depression or apathy.
5. Neuroprotection : Offers protection to the brain against damage, such as traumatic brain injuries or oxidative stress.
6. Increased cerebral blood flow : Improves circulation in the brain, which can result in enhanced cognitive function and greater brain health.
7. Improved sensory perception : Although it is a more subtle effect, some users report sharper, sharper perception after consuming pramiracetam.

Absorption: Since pramiracetam is fat-soluble, its absorption is influenced by the presence of fat. Below I explain how it is best absorbed:
Take with fat: Given its fat-soluble nature, pramiracetam is better absorbed when taken with a fat source. This can be a meal rich in healthy fats or an oil supplement, such as fish oil or MCT oil.
Oral route: Pramiracetam is usually taken orally in capsule or powder form.

Pramiracetam Adverse Effects: Although it is generally very well tolerated, for some there may be some side effects and contraindications to consider.

1. Headache: This is one of the most reported side effects with the use of racetams. Some believe this is due to a depletion of choline in the brain, and therefore supplementing with a source of choline (such as citicoline or Alpha GPC) may help prevent or reduce the incidence of this side effect.
2. Gastrointestinal discomfort: Some people may experience nausea, stomach upset, or diarrhea with pramiracetam.
3. Dry mouth: A less common but possible effect.
4. Insomnia: Although less common than with other racetams, some people may experience sleep disturbances if pramiracetam is taken later in the day.

Contraindications of Pramiracetam:

1. Drug Interaction: It is always crucial to consult with a doctor or pharmacist about possible interactions with medications you are already taking before starting pramiracetam.
2. Pre-existing conditions: People with a history of medical conditions, especially neurological or psychiatric conditions, should consult a doctor before taking pramiracetam.
3. Pregnancy and breast-feeding: The safety of pramiracetam during pregnancy and breast-feeding has not been fully investigated. As a precaution, it is best to avoid use during these periods.
4. High doses: Although pramiracetam is considered relatively safe, taking excessively high doses may increase the risk of side effects. It is always advisable to follow the dosage recommendations.

It is important to note that although pramiracetam has numerous potential benefits, it is always advisable that users conduct their own research and, if possible, consult with a health professional before beginning use.

More information about Pramiracetam and its dosage: https://nootropicsexpert.com/pramiracetam/

References on studies:

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[viii] Shih YH, Pugsley TA “The effects of various cognition-enhancing drugs on in vitro rat hippocampal synaptosomal sodium dependent high affinity choline uptake.” Life Sciences . 1985 Jun 3;36(22):2145-52. ( source )

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[x] Murai S., Saito H., Abe E., Masuda Y., Odashima J., Itoh T. “MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.” Journal of Neural Transmission 1994;98(1):1-13. ( source )

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[xiv] De Vreese LP, Neri M., Boiardi R., Ferrari P., Belloi L., Salvioli G. “Memory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot study.” Archives of Gerontology and Geriatrics . 1996;22 Suppl 1:9-22. ( source )

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