Sulbutiamine 250mg - 50 capsules

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) designed to overcome the blood-brain barrier more efficiently than regular thiamine. Developed in Japan in the 1960s, sulbutiamine has gained popularity in the decades since as a powerful nootropic.

Why is it considered a nootropic? A nootropic is a substance that can improve cognitive function without causing harm or significant side effects. Sulbutiamine improves various brain functions, including memory, attention and mood, which categorizes it within this group of substances.

Mechanism of action : It is known that, being a thiamine derivative, it increases the levels of thiamine pyrophosphate in the brain. This molecule is essential for the production of acetylcholine, a key neurotransmitter for memory and cognition. Additionally, sulbutiamine may also influence the dopamine and glutamate systems in the brain.

Benefits:

1. Memory improvement : Increases the capacity for retention and retrieval of information, enhancing short and long-term memory.
2. Increased mental energy : Being a derivative of vitamin B1, sulbutiamine can improve energy production at the cellular level, resulting in increased vigor and mental clarity.
3. Mood improvement : It has been observed that sulbutiamine can reduce symptoms of asthenia (fatigue), depression and improve general well-being.
4. Reduction of fatigue : Both physical and mental fatigue can be combated with sulbutiamine, which is especially useful for students, athletes and professionals.
5. Concentration enhancement : Facilitates the ability to maintain focus on specific tasks and attention for long periods.
6. Neuroprotective effects : It has been suggested that sulbutiamine may offer neuroprotective properties, helping to protect the brain against damage and cognitive decline.
7. Optimization of sports performance : Due to its ability to reduce fatigue and improve energy, it can be beneficial for athletes.
8. Improvement in motivation : An increase in motivation and desire to perform activities has been observed in those who consume sulbutiamine.
9. Therapeutic potential : Its use has been investigated to treat a variety of conditions, including vitamin B1 deficiencies and certain types of erectile dysfunction.
10. Improved learning ability : Sulbutiamine can enhance the brain's ability to learn and adapt to new information and experiences.

Absorption: It is fat soluble

1. Take with fats : Given its fat-soluble nature, sulbutiamine is better absorbed when consumed with a fat source. It may be beneficial to take it with a meal containing healthy fats or with an oil supplement, such as fish oil or MCT oil.
2. Oral route : Sulbutiamine is commonly taken orally, usually in capsule or tablet form.
3. Tolerance : It is important to mention that continuous use of sulbutiamine can lead to tolerance. This means that over time, you may need a higher dose to get the same effects. That's why some experts recommend taking it in cycles or with periodic breaks to avoid building a tolerance.

Adverse Effects of Sulbutiamine: Although it is generally considered very safe at recommended doses, for some there may be side effects and contraindications associated with its use.

1. Anxiety: Some people have reported an increase in anxiety levels after taking sulbutiamine, although this is not common.
2. Euphoria or irritability: There are anecdotal reports of elevated moods or irritability with sulbutiamine use.
3. Dermatitis: Rarely, some people may experience skin rashes, which could be an allergic reaction.
4. Insomnia: Some people may experience sleep disturbances, especially if taken later in the day.
5. Tolerance: There are reports that continued use may lead to reduced effects, suggesting the possibility of developing tolerance to sulbutiamine.

Contraindications of Sulbutiamine:

1. Drug Interaction: It is always essential to check with a doctor or pharmacist about possible interactions with medications you are already taking before starting sulbutiamine.
2. Pre-existing conditions: People with certain medical conditions, particularly those related to the nervous system, should proceed with caution and consult a doctor before starting a sulbutiamine regimen.
3. Pregnancy and breast-feeding: While there is no conclusive evidence of harm, the safety of sulbutiamine during pregnancy and breast-feeding has not been fully established. As a precaution, it is best to avoid use during these periods.
4. Allergies: People allergic to thiamine-related compounds should avoid sulbutiamine.

It is important to understand that, although sulbutiamine offers several potential benefits, its consumption must be done in an informed and responsible manner. As with any supplement, it is advisable that users conduct their own research and consult a health professional before beginning any supplementation regimen.

More information about Sulbutiamine and its dosage: https://nootropicsexpert.com/sulbutiamine/

References on studies:

[i] Wernicke-Korsakoff syndrome. Medline Plus Medical Encyclopedia nlm.nih.gov/medlineplus Retrieved April 7, 2016 ( source )

[ii] Martin PR, Singleton CK, Hiller-Sturmhofel S. “The Role of Thiamine Deficiency in Alcoholic Brain Disease” National Institute on Alcohol Abuse and Alcoholism nih.gov Retrieved April 7, 2016 ( source )

[iii] Singleton CK, Martin PR “Molecular mechanisms of thiamine utilization.” Current Molecular Medicine 2001 May;1(2):197-207. ( source )

[iv] Ollat H., Laurent B., Bakchine S., Michel BF, Touchon J., Dubois B. “[Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease]”. L'Encephale 2007 Mar-Apr;33(2):211-5.

[v] Benton D., Griffiths R., Haller J. “Thiamine supplementation mood and cognitive functioning.” Psychopharmacology 1997 Jan;129(1):66-71. ( source )

[vi] Tiev KP, Cabane J., Imbert JC “[Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo].” The Revue of Medicine Interne 1999 Oct;20(10):912-8. ( source )

[vii] Micheau J., Durkin TP, Destrade C., Rolland Y, Jaffard R. “Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation.” Pharmacology, Biochemistry and Behavior 1985 Aug;23(2):195-8. ( source )

[viii] Bizot JC, Herpin A., Pothion S., Pirot S., Trovero F., Ollat H. “Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatially delayed-non -match-to-sample task.” Progress in Neuro-psychopharmacology & Biology Psychiatry . 2005 Jul;29(6):928-35. ( source )

[ix] Sobolevsky T., Rodchenkov G. “Sulbutiamine in sports.” Drug Testing and Analysis 2010 Nov-Dec;2(11-12):643-6. ( source )

[x] Dmitriev DG, Gamidov SI, Permiakova OV “[Clinical efficacy of the drug enerion in the treatment of patients with psychogenic (functional) erectile dysfunction].” Urology 2005 Jan-Feb;(1):32-5. ( source )