Coluracetam 20mg - 50 capsules

Coluracetam is a nootropic derived from the racetam family. It was originally developed and patented by the Mitsubishi Tanabe Pharma company in Japan, and later studied to treat neurodegenerative diseases and cognitive disorders. Unlike other racetams, Coluracetam has a unique chemical structure that gives it particular characteristics.

Why is it considered a nootropic? It is categorized as a nootropic due to its properties to enhance and improve cognitive abilities. These effects include improved memory, learning, focus, and mental clarity.

Mechanism of action: Coluracetam's primary mechanism of action is its ability to enhance choline, specifically through modulation of the high-affinity choline transporter (HACU). HACU is the rate-limiting step in the synthesis of acetylcholine, a neurotransmitter crucial for cognitive function. By enhancing HACU, Coluracetam increases choline uptake in neurons, leading to enhanced acetylcholine production.

Benefits of Coluracetam:

1. Cognitive Improvement:
   • Memory: Coluracetam can help improve short- and long-term memory. This results in a greater ability to remember information, events, names and dates.
   • Learning: The speed and ability to acquire new knowledge can be benefited. This is especially useful for students and professionals who need to constantly learn.
   • Concentration and focus: Coluracetam can reduce mental fatigue and help maintain concentration during prolonged, challenging tasks. It is ideal for times of high cognitive stress or when sustained attention is required.
2. Improved Mood:
   • Anxiolytic properties: Coluracetam can help reduce anxiety levels, allowing for a calmer and more relaxed state of mind.
   • Antidepressant effect: Some reports and preliminary studies suggest that it may be useful in elevating mood and combating depressive symptoms. This could be related to its effect on acetylcholine and other neurotransmitters.
   • General well-being: In addition to reducing anxiety and depression, it can contribute to an overall feeling of well-being and satisfaction.
3. Sensory Enhancer:
   • Visual Perception: Some users have reported sharper and clearer perception of colors and shapes.
   • Auditory acuity: There may also be better perception and clarity in the auditory sense, allowing sounds to be discerned with greater precision.
4. Neuroprotection:
   • Protection against neuronal damage: Coluracetam may protect brain cells against certain types of damage, such as those induced by toxins or oxidative stress.
   • Support in neurodegenerative diseases: Although the research is preliminary, there are indications that coluracetam could be useful in the treatment or prevention of diseases such as Alzheimer's or Parkinson's.
5. Resilience to Stress:
   • Reducing cognitive stress: In situations of high mental demand, coluracetam may help maintain clarity and cognitive function.
   • Adaptation to physical stress: Although studies are limited, there is some evidence to suggest that coluracetam may help the brain better adapt to physically stressful situations.

Absorption: Although specific information on the absorption of Coluracetam is limited, in general, racetams are efficiently absorbed from the gastrointestinal tract. To maximize its absorption, some users prefer to take Coluracetam with foods containing fats, although this is not strictly necessary.

1. Headache: A common side effect among racetams, it is generally attributed to choline depletion.
2. Irritability or anxiety: Some users report mood swings or increased anxiety.
3. Fatigue: In some cases, it may cause tiredness or drowsiness.

1. Pregnancy and breast-feeding: As with many supplements and medications, use should be avoided during these periods due to lack of studies.
2. Drug interactions: It is always essential to consult with a health professional before combining Coluracetam with other medications or supplements.

It is important to emphasize that, while Coluracetam has a variety of potential benefits, the effects may vary between individuals. It is always essential that users do their own research and, if possible, consult with a health professional before incorporating it into their routine.

More information about Coluracetam and its dosage: https://nootropicsexpert.com/coluracetam/

Study references:

[i] Takashina K., Bessho T., Mori R., Eguchi J., Saito K. “MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats.” Journal of Neural Transmission (Vienna) . 2008 Jul;115(7):1027-35. ( source )

[ii] Akaike A., Maeda T., Kaneko S., Tamura Y. “Protective effect of MKC-231, a novel high affinity choline uptake enhancer, on glutamate cytotoxicity in cultured cortical neurons.” Japanese Journal of Pharmacology . 1998 Feb;76(2):219-22. ( source )

[iii] Ray B., Bailey JA, Simon JR, Lahiri DK “High-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in neuronal cultures for mechanistic and drug discovery studies.” Current Protocols in Neuroscience . 2012 Jul;Chapter 7:Unit 7.23. ( source )

[iv] “Uptake of Choline, a Precursor of Acetylcholine” Williams College williams.edu Retrieved May 3, 2016 ( source )

[v] Brauser D. “Neurogenesis-Stimulating Compounds Show Promise in the Treatment of Major Depression” Medscape Medical News September 21, 2009 ( source )

[vi] Bessho T., Takashina K., Eguchi J., Komatsu T., Saito K. “MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. ” Journal of Neural Transmission (Vienna). 2008 Jul;115(7):1019-25. ( source )

[vii] Murai S., Saito H., Abe E., Masuda Y., Odashima J., Itoh T. “MKC-231, a choline uptake enhancer, ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice.” Journal of Neural Transmission General Section . 1994;98(1):1-13. ( source )