Alpha Lipoic Acid 200mg - 100 capsules

Alpha Lipoic Acid (ALA) is a chemical compound that occurs naturally in the body and is also present in certain foods. It is known for its ability to function as a powerful antioxidant, and its versatility lies in the fact that it is soluble in both water and fat. This differentiates it from other antioxidants and allows it to work in multiple areas of the body.

Why is it considered a nootropic? It is considered a nootropic due to its beneficial effects on brain function and neuronal health. It helps protect brain cells from the harmful effects of free radicals, improves neuronal energy efficiency, and may support memory and cognition.

Mechanism of action:

• Powerful Antioxidant: ALA neutralizes free radicals in both aqueous and lipid environments, and also has the ability to regenerate other antioxidants, such as vitamins C and E.
• Modulation of Metabolism: Helps in the conversion of glucose into energy within cells, which is essential for brain and muscle function.
• Metal Chelating: ALA can bind and help eliminate certain toxic metals from the body.

1. Multifunctional Antioxidant:
   • Free Radical Neutralization: ALA is unique in its ability to neutralize free radicals in aqueous and lipid environments, meaning it can work almost anywhere in the body.
   • Regeneration of Other Antioxidants: Beyond its own antioxidant capacity, ALA can help regenerate other antioxidants, such as vitamins C and E, that have been "used up" neutralizing free radicals.
2. Improved Brain Function:
   • Neuronal Protection: ALA has been shown to protect brain cells from oxidative damage, which could reduce the risk of neurodegenerative diseases.
   • Cognitive Support: May improve memory and concentration by improving the energy efficiency of brain cells and protecting them from damage.
3. Glucose Regulation and Insulin Sensitivity:
   • Hypoglycemic Effect: ALA has been shown to reduce blood sugar levels in studies, making it beneficial for people with type 2 diabetes.
   • Improves Insulin Sensitivity: ALA can improve the way the body responds to insulin, which is essential for proper glucose utilization.
4. Liver Health:
   • Liver Protection: Due to its antioxidant properties, ALA can protect the liver from certain damages, such as those induced by excessive alcohol consumption or certain toxins.
   • Detoxification: ALA has been used in the treatment of heavy metal poisoning due to its chelating ability.
5. Treatment of Diabetic Neuropathy:
   • Pain Reduction: ALA has shown a remarkable ability to reduce the symptoms of diabetic neuropathy, especially pain.
   • Improved Nerve Function: Through its antioxidant properties, it can help improve the function of damaged nerves.
6. Skin Health and Beauty:
   • Protection Against Aging: By reducing oxidative damage, ALA can keep skin healthy and delay signs of aging.
   • Improves Texture and Shine: ALA can help improve skin texture and give it a natural glow by reducing inflammation and improving microcirculation in the skin.
7. Cardiovascular health:
   • Reduced Oxidative Stress: By reducing oxidative stress, ALA may contribute to blood vessel and heart health.
   • Improved Endothelial Function: ALA can improve the function of the endothelium, the inner lining of blood vessels, which can have a positive effect on blood pressure and overall circulation.

Alpha Lipoic Acid is a compound with multiple health benefits. Its versatility and broad spectrum of action make it suitable for a variety of uses and applications in the field of health and well-being.

Absorption: ALA is best absorbed when taken on an empty stomach. Supplemental forms of ALA (such as R-ALA) may offer superior bioavailability compared to forms found in foods.

Adverse Effects and Contraindications:

• Side Effects: Side effects are rare but may include skin rashes, nausea, or upset stomach.
• Drug Interaction: ALA can enhance the effects of diabetes medications, so those who are on antidiabetic medication should be cautious and consult a health professional.
• Contraindications: People with known allergies to ALA should avoid use. It is always advisable to consult a doctor before starting any supplementation, especially if you have any pre-existing medical conditions or are taking medication.

Alpha Lipoic Acid is a versatile supplement with a wide range of health benefits. However, as with all supplements, it is essential to use it responsibly and in proper doses. It is important to remember that supplements should not be seen as substitutes for a balanced diet and a healthy lifestyle.

More information about ALA and its dosage: https://nootropicsexpert.com/alpha-lipoic-acid/

References on studies:

[i] Panigrahi M., Sadguna Y., Shivakumar BR, Kolluri SV, Roy S., Packer L., Ravindranath V. “alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.” Brain Research . 1996 Apr 22;717(1-2):184-8. ( source )

[ii] Holmquist L., Stuchbury G., Berbaum K., Muscat S., Young S., Hager K., Engel J., Münch G. “Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.” Pharmacology and Therapeutics . 2007 Jan;113(1):154-64. ( source )

[iii] Ahmed HH “Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.” Experimental Toxicologic Pathology 2012 Sep;64(6):549-56. ( source )

[iv] Hager K., Kenklies M., McAfoose J., Engel J., Munch G. “Alpha-lipoic acid as a new treatment option for Alzheimer's disease—a 48-month follow-up analysis.” Journal of Neural Transmission. Supplementum. 2007;72:189-93. ( source )

[v] Biewenga GP, Haenen GR, Bast A. “The pharmacology of the antioxidant lipoic acid.” General Pharmacology 1997 Sep;29(3):315-31. ( source )

[vi] Shiqin Xiong, Nikolay Patrushev, Farshad Forouzandeh, Lula Hilenski, R. Wayne Alexander. PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases . Cell Reports , 2015; DOI: 10.1016/j.celrep.2015.07.047

[vii] Sherif S., Bendas ER, Badawy S. “The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle.” European Journal of Pharmaceutics and Biopharmaceutics 2014 Feb;86(2):251-9. ( source )

[viii] Berg JM, Tymoczko JL, Stryer L. “The Citric Acid Cycle Oxidizes Two-Carbon Units” Biochemistry. 5 th Edition WH Freeman, New York; 2002 ( source )

[ix] Liu J., Head E., Gharib AM, Yuan W., Ingersoll RT, Hagen TM, Cotman CW, Ames BN “Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid.” Proceeding of the National Academy of Sciences of the United States of America 2002 Feb 19;99(4):2356-61. ( source )

[x] Hermann R., Mungo J., Cnota PJ, Ziegler D. “Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms” Clinical Pharmacology 2014; 6: 195–204. ( source )

[xi] Carlson DA, Smith AR, Fischer SJ, Young KL, Packer L. “The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects.” Alternative Medicine Review 2007 Dec;12(4):343-51. ( source )